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Updated: Jun 16, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
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一种强效和持久的疟疾传染阻断疫苗,由单组件60个副本Pfs230D1纳米粒子设计而成

Nichole D Salinas1, Rui Ma1, Thayne H Dickey1

  • 1Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

NPJ vaccines
|August 18, 2023
PubMed
概括

使用Pfs230D1和E2p蛋白,开发了一种新的疟疾传播阻断疫苗 (TBV) 纳米粒子. 这种稳定,单组分的候选疫苗引发了强大的抗体反应,具有高的降低传播活性.

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Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...