相关实验视频

Updated: Jul 18, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

脊椎关节炎患者的肠道微生物群差异与布拉斯托菌殖民相关

Carlos Nieto-Clavijo¹, Liliana Morales¹, Ricaurte Alejandro Marquez-Ortiz²

¹Laboratorio de Parasitología Molecular, Vicerrectoría de Investigaciones, Universidad El Bosque, Edificio O. Segundo Piso, Avenida Carrera 9 #131A-02, Bogotá, Colombia.

Scientific reports

|August 18, 2023

概括

胚囊会影响健康个体的肠道微生物群多样性,但不影响脊椎关节炎 (SpA) 患者. 这表明SPA疾病因素可能会取代胚囊细胞对肠道微生物组合和功能的影响.

科学领域:

微生物组研究的研究.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

布拉斯托囊在肠道健康中的作用是有争议的.
它对诸如脊椎关节炎 (SpA) 等自身炎症性疾病的影响在很大程度上是未知的.

研究的目的:

为了研究SPA患者和对照人群之间的肠道微生物组差异.
确定布拉斯托囊菌殖民对SPA肠道微生物群的影响.

主要方法:

在36名SPA患者和13名对照中分析了肠道微生物组的丰富性,多样性和分类构成.
使用PICRUSt进行功能通路分析.

主要成果:

在SPA患者和对照人群之间观察到微生物丰富度,多样性和组成的显著差异.
在对照组中,囊胚细胞增加了微生物群的多样性,但在SPA患者中并非如此.
患有芽细胞瘤的SPA患者的Pseudomonadota增加,而非殖民的SPA患者的Bacilli和Clostridiaceae增加.
皮克鲁斯特在囊胚阳性患者和阴性SPA患者中发现了不同的功能途径,表明了潜在的保护机制.

结论:

在健康个体中,胚囊细胞可能会塑造肠道微生物群,但在SPA患者中,这种效果会减弱.
在SpA中,疾病特异性因素似乎主导着肠道微生物组调节.
在SPA患者中观察到的微生物组变化可能代表着对炎症的保护性反应.

更多相关视频

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

相关概念视频

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...