甲状腺功能与糖尿病外围神经病变之间的关联在2型糖尿病患者中
Qingyuan He1, Zekun Zeng1, Man Zhao1,2
1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Scientific reports
|August 18, 2023
概括
较低的自由甲状腺素 (FT4) 水平与2型糖尿病 (T2DM) 患者糖尿病外周神经病变 (DPN) 的风险更高有关. 这一发现强调了在T2DM管理中监测甲状腺功能的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 代谢疾病 代谢疾病
背景情况:
- 亚临床甲状腺功能低下症 (SCH) 和高甲状腺刺激激素 (TSH) 是已知的糖尿病外围神经病变 (DPN) 在2型糖尿病 (T2DM) 的风险因素.
- 甲状腺功能对无甲状腺T2DM患者的DPN的影响尚不清楚.
研究的目的:
- 为了研究甲状腺功能和DPN之间的关联,在乙甲状腺T2DM患者.
- 在这个人群中识别潜在的甲状腺相关生物标志物来确定DPN风险.
主要方法:
- 对580名无甲状腺T2DM患者的横截面研究,分为DPN和非DPN组.
- 统计分析包括曼-惠特尼U测试,奇方测试,斯皮尔曼相关性和后勤回归.
- 根据自由甲状腺素 (FT4) 水平,患者被分为四分之一,以评估DPN患病率.
主要成果:
- 与没有DPN的患者相比,Euthyroid T2DM患者的FT4和各种生物化学标志物的水平明显较低.
- FT4水平与多个临床指标有显著的相关性,包括总蛋白质,白蛋白和脂质.
- 在FT4水平和DPN患病率之间观察到负相关性,最低的FT4四分位数显示出最高的DPN风险.
结论:
- 降低的自由甲状腺素 (FT4) 水平与2型糖尿病 (T2DM) 患者糖尿病外周神经病变 (DPN) 的患病率和风险增加有关.
- 甲状腺功能,特别是FT4水平,可能在无甲状腺T2DM个体的DPN发展中发挥作用.
- 监测FT4可能有利于评估DPN风险在euthyroidT2DM患者.
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