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早期发病的胎儿生长限制增加了青少年的左心室球状性非常早产

Jonas Liefke^1,2, Alvaro Sepúlveda-Martinez^1,3, Snehlata Shakya¹

¹Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Pediatric cardiology

|August 18, 2023

概括

左心室形状的变化,特别是球形的增加,在非常早产的青少年中很明显,胎儿生长限制 (FGR) 有添加效应. 这种改变的形状可以预测这个人群的未来心血管疾病风险.

科学领域:

心脏病学心脏病学
发展生物学发展生物学
医疗成像医学成像

背景情况:

左心室 (LV) 形状变化与心血管结果有关.
众所周知,早产和胎儿生长限制 (FGR) 会影响心血管健康.
之前的研究表明,早产或有FGR的儿童的LV形状变化.

研究的目的:

为了研究非常早产的青少年的LV形状变化.
为了确定FGR是否对非常早产青少年的LV形状产生添加效应.
评估这个队列中LV形状的变化是否与未来心血管疾病风险相关.

主要方法:

心脏核磁共振扫描 (MRI) 测试对有或没有早产期FGR的早产期青少年,以及适合妊娠年龄 (AGA) 的早产期对照进行.
主要成分分析 (PCA) 用于分析 LV 形状的变化在终止腹痛,终止心痛和组合阶段.
还评估了LV质量和射出分数以评估心脏功能.

主要成果:

在非常早产的青少年中,与满期出生的AGA对照人群相比,LV球状度增加.
早期发病的FGR在非常早产的青少年中加剧了LV球状性,这表明了附加效应.
两组之间没有发现LV质量或射出分数的显著差异.

结论:

非常早产导致LV重塑,其特点是球状性增加.
早期发病的FGR对非常早产的青少年的LV形状产生了附加的有害影响.
增加的LV球性可能作为未来心血管疾病的预后生物标志物,在这个脆弱的人群中,即使没有当前的功能缺陷.

关键词:

进行心脏重塑.胎儿生长限制胎儿生长限制过早交付的时间过早交付.形状分析形状分析

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