肠道微生物群的差异是由韩国流浪猫的Toxoplasma gondii血清阳性引起的
Sooji Hong1,2, Jun Ho Choi3, Singeun Oh3
1MediCheck Research Institute, Korea Association of Health Promotion, Seoul, 07649, Korea.
Parasitology research
|August 18, 2023
概括
毒素菌感染显著改变流浪猫的肠道微生物群,减少多样性和增加潜在的病原体,如Escherichia. 这凸显了监测这些动物感染水库的必要性.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 微生物组研究 微生物组研究
- 猫类传染病 猫类传染病
背景情况:
- 毒素菌是一种广泛传播的寄生虫,猫是最终宿主.
- T. gondii对猫肠道微生物群的影响仍未得到充分研究.
- 流浪猫是动物传播疾病的潜在储库.
研究的目的:
- 研究T. gondii感染对流浪猫肠道微生物群的影响.
- 在感染的流浪猫中识别潜在的便病原体.
- 为了将T. gondii血清状态与肠道微生物组合相关联.
主要方法:
- 血液样本被用于确定T. gondii感染状态 (血清阳性).
- 用16S rRNA基因安普利康序列分析便样本,以评估肠道微生物群.
- 计算了操作分类学单位 (OTU) 和香农多样性指数.
主要成果:
- 在T. gondii病毒阳性和病毒阴性猫之间观察到肠道微生物群组成和多样性的显著差异.
- 阳性猫的微生物多样性减少 (较低的OTU和香农指数).
- 在血清阳性猫中丰富Escherichia和Enterobacteriaceae;在血清阴性猫中丰富Collinsella,Bifidobacterium和Roseburia.
- 在便样本中检测到像Campylobacter,Escherichia和Streptococcus这样的潜在病原体.
结论:
- 淋巴菌感染显著影响流浪猫的肠道微生物群多样性和组成.
- 埃舍里希亚种类 (Escherichia spp.) 的存在 在T. gondii感染的猫身上增加了负载,表明潜在的病原体存在率更高.
- 监测流浪猫的动物传染病原体是至关重要的,因为它们作为疾病储存器的作用.
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