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内分泌和血管内皮生长因子的表达及其与染细胞瘤发病学预后参数的相关性

Muhammet Kocabaş¹, Mustafa Can², Melia Karaköse³

¹Department of Internal Medicine, Division of Endocrinology and Metabolism, Tokat State Hospital, Tokat, Turkey.

|August 18, 2023

概括

内膜和血管内皮生长因子 (VEGF) 在色细胞瘤瘤中显著升高,与恶性瘤潜力相关. 这些标志物可以作为染细胞瘤的诊断和预后指标.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
病理学病理学病理学

背景情况:

内膜和血管内皮生长因子 (VEGF) 是各种高度血管性癌症的已知标志物,具有预后意义.
它们在罕见的上腺瘤 - - 色细胞瘤中的作用需要进一步阐明.

研究的目的:

调查染细胞瘤组织中内分泌和VEGF的表达水平.
评估内分泌和VEGF表达和组织病理学参数之间的相关性,包括恶性瘤潜力.

主要方法:

在38个染细胞瘤和28个正常的上腺髓样本中对内分泌和VEGF表达的免疫组织化学分析.
通过上腺瘤尺度得分 (PASS) 和Ki-67指数对其遗传病理参数进行评估.

主要成果:

与正常的上腺髓相比,内分泌和VEGF表达在色细胞瘤组织中显著更高.
内分泌表达与 PASS 总分数及其组成部分正相关.
VEGF表达与更高的Ki-67指数,总的PASS得分,瘤细胞结和核形有关.

结论:

恩多坎和VEGF在染细胞瘤上升调节,并与恶性瘤潜力增加有关.
恩多坎显示出作为瘤标志物和预测色细胞瘤恶性瘤的潜力.
发红细胞瘤中VEGF检测与恶性瘤增加的指标相关.

关键词:

上腺髓上腺髓在内分泌体内,内分泌体内.免疫组织化学免疫组织化学通过通过通过通过.染细胞瘤 (Pheochromocytoma) 是一种细胞瘤.血管内皮生长因子血管内皮生长因子

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