非特异性心室内导电延迟预测了扩张性心肌病的预后
Yong Yuan1,2, Kai Yang1, Qianjun Liu3
1Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
BMC cardiovascular disorders
|August 18, 2023
概括
非特异性心室内导电延迟 (NSIVCD) 是扩张性心肌病 (DCM) 患者的不良预后标志物. 这一发现独立于其他关键的临床因素,强调了NSIVCD在DCM预后中的重要性.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心血管成像 - 心血管成像
背景情况:
- 左捆支部阻塞 (LBBB) 是已知的扩张性心肌病 (DCM) 的不良预后指标.
- 在DCM中对非特异性静脉内导电延迟 (NSIVCD) 的预后数据有限且相互矛盾.
研究的目的:
- 为了评估NSIVCD在DCM患者的预后意义.
- 为了比较DCM患者的结果NSIVCD与那些LBBB,RBBB和没有静脉管导延迟 (IVCD) 的患者.
主要方法:
- 548名接受心血管磁共振成像 (CMR) 的DCM患者被分为四组:LBBB,RBBB,NSIVCD和没有IVCD.
- 对于包括心血管死亡,心脏移植和恶性心律不整合症在内的复合终点,患者的中位数为58个月.
- 使用卡普兰-梅尔分析和Cox比例危险回归来分析IVCD模式和结果之间的关联.
主要成果:
- 与没有IVCD患者相比,NSIVCD和LBBB患者的事件发生率较高;RBBB没有显著差异.
- 多变量考克斯回归确定了LBBB,NSIVCD,NYHA类,LVEF,LVEDDI,LGE%和GLS作为DCM中不良结果的独立预测因素.
- 队列的平均年龄为46±15岁,其中72.6%是男性.
结论:
- 非特异性心室内导电延迟 (NSIVCD) 是DCM患者的独立不良预后标志物.
- 这种NSIVCD的预后值不论其他临床参数如LVEDDI,NYHA类,LVEF,LGE%和GLS.
- 这些发现强调了识别和评估NSIVCD在DCM管理中的临床重要性.
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