短链脂肪酸在疾病中的作用
Dan Zhang1, Yong-Ping Jian1,2, Yu-Ning Zhang1
1Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun, 130021, China.
由肠道细菌发酵食纤维产生的短链脂肪酸 (SCFA) 对肠道健康和宿主新陈代谢至关重要. 这些代谢物影响肠道细胞,免疫反应和代谢疾病.
科学领域:
- 微生物学与新陈代谢
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 短链脂肪酸 (SCFA) 是来自食纤维的肠道微生物发酵的关键代谢物.
- 脂肪酸通过特定的载体被吸收,为肠上皮细胞 (IEC) 提供燃料,并影响宿主生理.
- 微生物代谢产物越来越多地被认为是它们在饮食与宿主相互作用中的作用.
研究的目的:
- 审查SCFA的各种功能角色.
- 讨论SCFA对肠道和代谢疾病的影响.
- 突出SCFA作为微生物对宿主影响的关键媒介.
主要方法:
- 关于SCFA的产生,吸收和功能研究的文献综述.
- 分析SCFA在细胞代谢和基因表达中的作用.
- 检查SCFA在各种生理过程和疾病中的参与.
主要成果:
- SCFA调节IEC,促进GLP-1分泌并抑制血糖升高.
- 在SCFA中,SCFA调节G蛋白合受体 (GPR41,GPR43) 和基因素脱乙酶.
- 主要的SCFA (乙酸,酸,丁酸) 影响免疫力,亡,炎症和脂质代谢.
结论:
- 类脂肪酸是肠道功能,宿主新陈代谢和免疫平衡的关键调节者.
- SCFA 生产或信号的调节失调有助于各种疾病.
- 了解SCFA的功能为代谢和肠道疾病提供了治疗潜力.
更多相关视频
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
09:39Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
相关概念视频
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Lipid Catabolism
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
