采用细胞疗法的挑战和新技术
Pengchao Zhang1,2, Guizhong Zhang3, Xiaochun Wan4
1Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Nanshan District, Shenzhen, 518055, People's Republic of China.
化学抗原受体 (CAR) -T细胞疗法对血液癌症有希望,但存在局限性. 新的CAR工程免疫细胞,如CAR-NK和CAR-巨细胞,为改善癌症免疫疗法提供了潜在的解决方案.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 采用细胞疗法 (ACT) 已经显著发展,仿真抗原受体 (CAR) -T细胞疗法彻底改变了血液恶性瘤治疗.
- 尽管取得了成功,但CAR-T细胞疗法在自主和异种应用中面临实用性和毒性方面的挑战.
研究的目的:
- 审查超越CAR-T细胞的新型CAR-工程免疫细胞疗法的发展,优势和挑战.
- 讨论免疫治疗中的基因转导策略,并探索癌症治疗的未来方向.
主要方法:
- 审查关于采用细胞疗法的现有文献,重点关注CAR工程.
- 分析新兴的基于CAR的细胞疗法,包括CAR-NK,CAR-巨细胞,CAR-γδT和CAR-NKT细胞.
- 讨论基因转导技术和创建积极反免疫电路的策略.
主要成果:
- CAR工程已经扩展到各种免疫细胞,导致CAR-NK,CAR-巨细胞,CAR-γδT和CAR-NKT疗法.
- 基因转导策略对于免疫疗法中有效的免疫细胞工程至关重要.
- 积极反免疫电路可以克服单细胞类型ACT的局限性.
结论:
- 新型CAR-工程免疫细胞有潜力克服CAR-T细胞治疗的局限性.
- 先进的基因转导和免疫电路的发展是未来癌症免疫治疗的关键.
- 将CAR技术扩展到各种免疫细胞具有显著的治疗前景.
更多相关视频
10:24Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
Published on: October 5, 2015
06:37Flotation-Based T Cell Isolation, Activation, and Expansion from Human Peripheral Blood Mononuclear Cell Samples Using Microbubbles
Published on: December 23, 2022
相关概念视频
Forced Transdifferentiation
Artificial...
Tumor Immunotherapy
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
iPS Cell Differentiation
Cell-mediated Immune Responses
