在巴西重大烧伤中引起感染的主要病原体和抗生素耐药性概况,比较两个时期:2015/2016年和2019/2020年
Nicoli Gueno Rissetto1, Julia Werner de Oliveira1, Renato Nisihara1
1Department of Medicine, Mackenzie Evangelical School of Medicine, Curitiba, Paraná, Brazil.
概括
败血症仍然是严重烧伤患者的主要死亡原因. 这项研究发现,燃烧患者的阳性培养增加,死亡率更高,Pseudomonas aeruginosa是主要病原体,尽管抗生素耐药性没有变化.
科学领域:
- 传染性疾病 传染性疾病
- 烧伤护理 烧伤护理
- 临床微生物学 临床微生物学
背景情况:
- 败血症是严重烧伤患者的关键并发症和主要死亡原因.
- 了解不断变化的致病因子和抗生素耐药性模式对于有效的治疗策略至关重要.
研究的目的:
- 在重大烧伤患者中识别主要的传染病原体及其抗生素耐药性概况.
- 分析流行病学数据,包括住院时间和受烧伤影响的身体总表面积 (TBSA).
- 在两个不同的时间段 (2015/2016和2019/2020) 中比较这些因素,以确定趋势.
主要方法:
- 从巴西一家参考医院的医疗记录进行了回顾性分析.
- 收集和比较烧伤人口统计数据,感染病原体和抗生素耐药性概况的数据.
- 统计分析以比较两个研究时期的结果.
主要成果:
- 观察到阳性培养率 (58.7%至80%) 和皮肤穿孔培养收集率显著增加.
- 在这两个时期, Pseudomonas aeruginosa,Acinetobacter baumannii (耐碳胺) 和 Staphylococcus aureus 是主要的病原体.
- 死亡率在后期增加 (26.2%对14.6%),败血症是死亡的主要原因,通常与P. aeruginosa.有关.
结论:
- 尽管取得了进展,但重大烧伤护理仍面临着细菌感染和败血症的持续挑战.
- 增加的积极培养可能反映出改进的诊断努力或更高的感染率.
- 像P. aeruginosa这样的多抗药生物体的持续流行需要在烧伤单位进行持续的监测和抗菌管理.
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