在多中心倾向性得分匹配研究中,怀孕期间患重症COVID-19的风险增加
Liviu Cojocaru1,2,3, Myint Noe4, Autusa Pahlavan5
1Division of Anesthesia Critical Care, Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Journal of perinatal medicine
|August 19, 2023
概括
感染COVID-19的孕妇面临严重疾病和并发症的风险增加. 这项研究强调了监测孕妇与2019年冠状病毒疾病相关的不良结果的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 怀孕可以改变女性的免疫系统,可能增加对感染的易感性.
- 了解COVID-19对孕妇的影响对于临床管理和公共卫生战略至关重要.
研究的目的:
- 为了调查COVID-19严重程度和怀孕结果之间的关联.
- 为了比较Covid-19的严重程度得分,住院率,以及孕妇和非孕妇之间的重症监护室 (ICU) 住院率.
主要方法:
- 追溯性多中心队列研究分析了针对SARS-CoV-2检测的成年女性 (18-45岁) 的图表.
- 怀孕病例与非怀孕对照之间的COVID-19严重性得分,住院,ICU入院,氧气使用,机械通风和死亡的比较.
- 倾向性得分匹配用于控制混因素.
主要成果:
- 怀孕妇女的中度至重度COVID-19的比例较高 (25%与16.1%相比).
- 在孕妇队列中观察到更高的住院率 (25.6%与17.2%相比),ICU入院率 (8.9%与4.4%相比) 和侵入性机械通风 (5.6%与2.8%相比),尽管在匹配后并不显著.
- 怀孕并发症 (40.7%),包括高血压疾病 (20.1%) 的显著率被注意到.
结论:
- 怀孕期间的COVID-19与疾病严重程度的增加有关.
- 怀孕与感染SARS-CoV-2的并发症风险更高有关.
- 这些发现强调了需要仔细监测和管理COVID-19的孕妇.
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