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对贝尔祖提凡的群体药理动力学分析,以告知剂量考虑和标签

Dhananjay D Marathe1, Petra M Jauslin2, Huub Jan Kleijn2

  • 1Merck & Co., Inc., Rahway, New Jersey, USA.

CPT: pharmacometrics & systems pharmacology
|August 19, 2023
PubMed
概括

贝尔祖提凡是一种低氧诱导的2α因子抑制剂,在VHL患者中显示出可预测的药理动力学. 对于UGT2B17和CYP2C19酶的双重低代谢者,药物暴露显著增加.

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