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在糖尿病足中进行多参数 perfusion 评估的可行性,使用 Intravoxel 不连贯运动和依赖血液氧化水平的MRI

Scott J Edwards¹, Jingting Yao^2,3,4, Marcos C Schechter^5,6

¹Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA.

Journal of magnetic resonance imaging : JMRI

|August 19, 2023

概括

声内不连贯运动 (IVIM) 和依赖血氧水平 (BOLD) 的MRI揭示了糖尿病足 (DFU) 的微血管变化. 这些先进的MRI技术表明DFU患者的高 perfusion,有助于区分 perfusion 异常.

科学领域:

医疗成像医学成像
糖尿病学糖尿病学
血管生物学血管生物学

背景情况:

2型糖尿病 (T2DM) 患者因微血管功能受损而面临糖尿病足 (DFU) 的风险增加.
德发育和延迟愈合与T2DM的潜在微血管疾病密切相关.
评估微血管变化对于理解和管理DFU并发症至关重要.

研究的目的:

确定声内不连贯运动 (IVIM) 和血氧水平依赖 (BOLD) MRI 在检测DFU患者微血管变化的灵敏度.
调查先进的MRI技术在糖尿病足并发症的背景下用于表征血管功能障碍的实用性.

主要方法:

一项涉及20名参与者的病例控制研究:10名T2DM患者患有DFU,5名T2DM患者没有DFU (DC) 和5名健康对照 (HC).
使用3TMRI与多b值IVIM序列来评估静止微血管参数 (D,D*,f,MVF).
在袖口诱导的缺血和再注射期间使用动态BOLD成像来评估中部脚部 (MP) 和侧部脚部 (LP) 区域的微血管反应性.

主要成果:

与DC患者相比,DFU患者在双脚区域呈现显著升高的D*,f和MVF.
在DFU患者和DC患者的MP区域观察到扩散系数 (D) 的增加.
与HC相比,DC患者在MP区域显示出输液分数 (f) 和微血管体积分数 (MVF) 的降低.
与DC相比,DFU组在LP和两个区域分别表现出缺血性耐受性受损和的再输液反应,与DC相比.

结论:

结合的IVIM和BOLDMRI有效地区分了糖尿病患者脚部的输液异常.
研究结果表明,DFU患者存在高 perfusion 的状态,突出显著的微血管变化.
这些MRI技术对DFU的临床评估和管理充满希望.

关键词:

这是一个大胆的表现.第四十一章没有了糖尿病糖尿病患者糖尿病患者糖尿病足部糖尿病足部 perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion 这是一个非常重要的方法,它可以让一个人觉得自己是个好的人,而不是一个好的人,而是一个好的人,而是一个好的人.反应性高血症反应性高血症

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