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Updated: Jul 18, 2025

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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针对前列腺癌的HIF-1:临床前证据的综合

Yarden Zohar1, Nicola J Mabjeesh1

  • 1Department of Urology, Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.

Expert opinion on therapeutic targets
|August 19, 2023
PubMed
概括

向缺氧诱导因子 (HIF) 显示出治疗侵袭性前列腺癌 (PC) 的前景. 研究探索HIF抑制剂,包括FDA批准的药物,用于PC治疗,解决瘤生长和抵抗.

关键词:
雄激素受体的受体 雄激素受体在HIF中,我们可以看到HIF.抗割的抗割材料缺氧诱导因子的诱导因子临床前研究 临床前研究前列腺腺腺癌前列腺腺腺癌前列腺癌是前列腺癌.

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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