系统性硬化和匹配对照中的并发症和死亡率:间歇性肺病的影响. 一个基于健康登记数据的基于人口的队列研究
Malene Knarborg1,2, Charlotte Hyldgaard3, Elisabeth Bendstrup4,5
1Department of Medicine, Lillebaelt Hospital, Vejle, Denmark.
伴随性疾病显著增加了系统性硬化症 (SSc) 患者的死亡率,特别是那些患有间歇性肺病 (ILD) 患者. 早期诊断和SSc并发症的管理对于改善患者的结果至关重要.
科学领域:
- 风湿病学和免疫学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,具有显著的发病率和死亡率.
- 间歇性肺病 (ILD) 是SSc的常见和严重并发症,进一步影响患者的预后.
- 伴随性疾病在SSc死亡率中的作用,特别是在ILD的背景下,需要进一步研究.
研究的目的:
- 评估伴随性疾病对系统性硬化症 (SSc) 患者死亡率的影响.
- 为了比较SSc患者与没有间歇性肺病 (ILD) 之间的死亡风险.
- 确定与SSc.死亡率增加相关的特定人口因素.
主要方法:
- 一项基于人口的匹配队列研究,使用丹麦国家患者登记册 (2002-2015).
- 有SSc的患者被分为具有ILD (SSc-ILD) 的SSc和没有ILD的SSc (非ILDSSc) 队列.
- 与一般人群对照进行1:4匹配;使用Deyo-Charlson并发症评分 (DCcs) 评估并发症.
主要成果:
- 与对照组相比,SSc患者的死亡危险比率 (HR) 增加了2.8倍.
- 与非ILD SSc.患者相比,SSc-ILD患者死亡的HR显著更高 (4.2).
- 在男性,年轻成年人 (18-50岁) 中观察到死亡率增加,与非ILD SSc.中较高的DCc相关.
结论:
- 伴随性疾病在全身性硬化症患者中显著增加死亡风险.
- 间歇性肺病是SSc.中过度死亡率的主要原因之一.
- 对SSc患者来说,及时诊断和对器官参与和并发症的全面管理至关重要.
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