作为一种治疗原则的迷走神经刺激
1MK II Rheumatologie, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Germany. olga.seifert@medizin.uni-leipzig.de.
Zeitschrift fur Rheumatologie
|August 19, 2023
概括
平衡自主神经系统,特别是增加副交感基调,可以改善类风湿性关节炎治疗反应. 生物电子干预为治疗风湿性疾病提供了潜在的非药物治疗方法.
科学领域:
- 神经免疫学 神经免疫学
- 自主神经系统生理学 自主神经系统生理学
- 类风湿病学 类风湿病学
背景情况:
- 慢性炎症性疾病,包括类风湿性关节炎 (RA),与失衡的自主神经系统有关,具有降低的副交感和增加的交感活动.
- 在RA患者中,这种自主性失衡预示着对抗瘤坏死因子 (TNF) 疗法的反应较差.
- 副交感神经系统的调节失调会影响促炎性细胞因子的产生.
研究的目的:
- 探索自主神经系统调制在炎症性疾病中的作用.
- 研究恢复自主平衡的潜力,以改善类风湿性关节炎的治疗结果.
- 突出生物电子干预作为潜在的非药物治疗风湿性疾病的非药物治疗策略.
主要方法:
- 对慢性炎症条件下自主神经系统活性现有研究的审查.
- 分析了类风湿性关节炎患者的自主平衡和治疗反应之间的关系.
- 考虑放荡神经的电刺激作为一种恢复自主平衡的方法.
主要成果:
- 降低的副交感和增加的交感活动是慢性炎症疾病的特征,并预测RA中对抗TNF治疗的反应不佳.
- 恢复自主平衡,可能通过迷走神经刺激,可以提高治疗效率.
- 生物电子方法正在成为类风湿性疾病药物治疗的潜在补充剂.
结论:
- 调节副交感音调具有显著的生理效应,包括减少炎症.
- 自主神经系统平衡是类风湿性关节炎治疗反应的关键因素.
- 对神经免疫学和生物电子疗法进行进一步的研究是需要在类风湿性疾病的新策略.
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