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皮肤状甲状腺微癌的射频切除后续策略:定义对切除的反应系统

Xinyang Li^1,2, Lin Yan², Jing Xiao²

¹School of Medicine, Nankai University, No.94 Weijin Road, Nankai District, 300071, Tianjin, China.

European radiology

|August 19, 2023

概括

一个新的响应移除系统有效地预测了在射频移除 (RFA) 后患有低风险乳头甲状腺小癌 (PTMC) 的患者的结果. 该系统将患者分为完整的,不确定的或不完整的响应组,指导个性化后续策略.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
医疗成像医学成像

背景情况:

乳头甲状腺微瘤 (PTMC) 是最常见的甲状腺癌类型.
射频除 (RFA) 是低风险PTMC的最小侵入性治疗选择.
预测临床结果和为PTMC患者量身定制后续治疗后RFA仍然是一个挑战.

研究的目的:

定义和验证一种响应-去除系统,用于预测RFA治疗的低风险PTMC患者的临床结果.
利用基于2015年美国甲状腺协会指南的动态风险分层.
为这些患者指导个性化后续策略.

主要方法:

对748名患有低风险PTMC且接受RFA (2014-2018) 的患者进行了回顾性审查.
根据1年的随访,分类为完整的,不确定的和不完整的响应组.
主要终点:局部瘤进展 (LTP) 和无病生存期 (DFS).

主要成果:

响应-消去系统显示出高预测准确度 (C指数:0.79).
长期治疗率有显著差异:1%在完全响应组,8.1%在不确定组,100%在不完全响应组.
在三个响应组中观察到DFS的显著差异 (p < 0.001).

结论:

定义的响应-去除系统有效地将PTMC患者RFA后分类为不同的临床结果队列.
这个系统为管理PTMC提供了一个新的范式,使得风险分层的后续行动成为可能.
该系统有助于定制持续的后续建议,以改善患者管理.

关键词:

没有疾病的生存率.乳头甲状腺小癌的小细胞甲状腺小癌.无线电频率剥离法无线电频率剥离法超声波学超声波学超声波学

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