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活性氧物种,毒性,氧化应激和抗氧化剂:慢性疾病和衰老
Klaudia Jomova1, Renata Raptova2, Suliman Y Alomar3
1Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, Nitra, 949 74, Slovakia.
Archives of toxicology
|August 19, 2023
概括
氧化应激,反应性氧/物种 (ROS/RNS) 的不平衡,有助于许多慢性疾病. 抗氧化剂和新的治疗策略对于减轻其有害影响和促进健康至关重要.
科学领域:
- 生物化学和分子生物学
- 细胞生理学 细胞生理学
- 病理学 病理学 病理学
背景情况:
- 活性氧/物种 (ROS/RNS) 在生理上存在于氧化应激,调节细胞功能.
- 来自内源或外源的ROS/RNS水平升高会导致氧化应激,这是一种与慢性疾病相关的有害状况.
- 氧化压力是各种疾病的常见病理分母,包括癌症,心血管,神经和精神疾病.
研究的目的:
- 审查氧化应激在疾病发病过程中的重要性.
- 阐明导致ROS/RNS生成的化学机制及其有害影响.
- 讨论氧化应激生物标志物和治疗干预措施的评估.
主要方法:
- 关于氧化应激,ROS/RNS化学和相关病理的科学文献的综述.
- 对细胞组件 (DNA,蛋白质,脂质) 的氧化损伤机制的分析.
- 讨论抗氧化剂防御系统和新兴的治疗策略.
主要成果:
- 详细检查ROS/RNS化学成分,包括超氧化基,过氧化和过氧化.
- 识别由ROS/RNS调制的关键信号通路,如NF-κB,MAPK和Nrf2.
- 综合了与氧化压力相关的疾病,包括癌症,糖尿病,神经退行性疾病和衰老.
结论:
- 氧化应激是许多慢性疾病的发展和进展的关键因素.
- 抗氧化酶和小分子,如维生素E,对抗氧化损伤至关重要.
- 新兴的策略,包括特定的抗氧化剂和氧化还原金属基化合物,显示出治疗干预和抗衰老的前景.
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