硫转移酶XB5850668.L是需要分配胚胎外皮领域的
Alexander Marchak1, Karen M Neilson1, Himani D Majumdar1
1Department of Anatomy and Cell Biology, George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia, USA.
概括
Six1调节XB5850668.L,这是一个硫转移酶 (SULT2),对胚胎内皮外皮模式很重要. 它的活动影响神经板,神经和胚胎发生期间的胎盘发育.
科学领域:
- 发育生物学是发展生物学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 硫转移酶超级家族 (SULT) 酶调节各种生物分子,但它们在胚胎发育中的作用尚不清楚.
- 发现Six1,一个关键的发育调节剂,可以对LOC100037047进行上调调节,该调节剂编码非特征的硫转移酶XB5850668.L.L.
研究的目的:
- 为了研究胚胎外皮格局中未经表征的硫转移酶XB5850668.L的功能.
- 确定XB5850668.L在由发育基因Six1.1.L调节的过程中的作用.
主要方法:
- 功能损失和功能增益的测试被用来研究XB5850668.L.L.
- 分析了神经板,神经,头骨和耳囊的基因表达域.
- 进行了硫转移酶催化域的突变发生,以评估酶活性的作用.
主要成果:
- 击败XB5850668.L导致表皮,神经,头骨和耳囊基因的表达减少,同时神经板扩张.
- 过度表达XB5850668.L有轻微的影响,偶尔会扩大神经板和神经域,同时减少斑点和眼囊域.
- 突变XB5850668.L的关键催化残留物减少了野生类型蛋白质过度表达所观察到的效应.
结论:
- XB5850668.L是SULT2家族中的一个成员,对胚胎内皮外皮模式至关重要.
- 观察到的XB5850668.L对发育的影响部分取决于其硫转移酶酶活性.
关键词:
在LOC10003704747中使用.第六百零一章 六一这是Xenopus.神经边界的神经边界神经峰的神经峰神经板是神经板的一个组成部分.眼球囊泡 眼球囊泡在此之前,Preplacodal ectoderm 已经成为一种常见的产物.更多相关视频
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