使用levonorgestrel加Piroxicam的口服紧急避孕药:一个随机双盲,安慰剂对照试验
Raymond Hang Wun Li1, Sue Seen Tsing Lo1, Kristina Gemzell-Danielsson2
1Department of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; The Family Planning Association of Hong Kong, Hong Kong Special Administrative Region, China.
将皮罗西卡姆添加到莱沃诺格斯特勒中显著提高了紧急避孕 (EC) 的有效性. 这种组合可以防止比单独使用levonorgestrel更多的预期怀孕,提供更有效的EC选择.
科学领域:
- 生殖健康
- 药理学
- 临床试验
背景情况:
- 利沃诺格斯特勒是一种标准的紧急避孕药物,但其在排卵后的有效性有限.
- 环氧酶抑制剂可能与莱沃诺格斯特勒具有协同作用,从而提高EC疗效.
研究的目的:
- 调查是否同时使用单剂量40mg的皮罗西卡姆和莱沃诺格斯特勒可以提高紧急避孕的疗效.
- 评估皮罗西卡姆在使用莱沃诺格斯特勒EC的辅助剂时对怀孕预防率的影响.
主要方法:
- 这是一项随机,双盲,安慰剂对照试验,涉及860名需要使用levonorgestrel EC的妇女.
- 参与者接受了Levonorgestrel 1.5 mg加Piroxicam 40 mg或Levonorgestrel加安慰剂.
- 在预期月经1至2周后评估怀孕状况;主要结局是预防怀孕.
主要成果:
- 皮罗西卡姆组的怀孕率为0. 2% (1/418),而安慰剂组的怀孕率为1. 7% (7/418).
- 在预期的怀孕中,Levonorgestrel加Piroxicam可预防94. 7%,而Levonorgestrel加安慰剂可预防63. 4%.
- 两组之间没有观察到月经周期变化或不良事件概况的显著差异.
结论:
- 在该研究中,口服Piroxicam 40 mg与Levonorgestrel同时使用显著改善了EC疗效.
- 皮洛西卡姆的同时使用可能是加强基于levonorgestrel的紧急避孕措施的临床考虑.
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