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蛋过敏和黄热病疫苗接种 疫苗接种
Bárbara L B Cançado1, Carolina S Aranda1, Marcia C Mallozi1
1Universidade Federal de São Paulo, Divisão de Alergia, Imunologia Clínica e Reumatologia, São Paulo, SP, Brazil.
Jornal de pediatria
|August 19, 2023
概括
黄热病疫苗 (YFV) 可以安全地给怀疑患有蛋过敏的人接种. 对YFV和卵子组件,特别是卵体的阳性皮肤测试与反应严重程度相关,指导疫苗接种决策.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 过敏学 过敏学
背景情况:
- 由于疫苗生产方法,患有蛋过敏的人经常面临有关黄热病疫苗 (YFV) 管理的担忧.
- 识别可靠的生物标志物对于在这个人群中安全管理YFV疫苗接种至关重要.
- 了解免疫接种后不良事件 (AEAI) 的风险因素对于患者安全至关重要.
研究的目的:
- 评估生物标志物,以安全指导黄热病疫苗 (YFV) 接种在怀疑蛋过敏的个体.
- 确定与免疫接种后不良事件 (AEAI) 风险增加相关的因素.
主要方法:
- 患者接受了皮肤刺伤测试 (SPT) 和皮内测试 (IDT) 以蛋过敏原和YFV.
- 测量了各种蛋蛋白的血清特异性IgE (sIgE) 水平.
- 对敏感的患者进行了YFV脱敏;其他人接受了YFV并受到监测.
主要成果:
- 招募了103名患者,71%的患者对YFV有反应.
- 阳性YFV皮肤测试结果与反应严重程度显著相关 (OR:7.64).
- 特定的IgE对ovomucoid是唯一与临床症状相关的生物标志物 (p=0.025).
结论:
- 阳性卵子成分测试和临床反应严重程度之间存在相关性.
- 卵和蛋白可能是潜在的指标,但需要进一步的研究.
- 当前的建议支持在必要时使用YFV测试作为疫苗接种指南.
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