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相关概念视频

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

226
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
226
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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相关实验视频

Updated: Jul 18, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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长时间起作用的微针配方.

Lalitkumar K Vora1, Akmal H Sabri1, Yara Naser1

  • 1School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

Advanced drug delivery reviews
|August 19, 2023
PubMed
概括
此摘要是机器生成的。

微针 (MN) 贴片为长效药物输送提供了注射的无痛替代品. 本综述探讨了持续治疗释放的MN设计和配方,旨在改善患者的遵从性和治疗结果.

关键词:
有控制释放的释放.皮肤内通路径 皮肤内通路径长效药物输送是长效药物输送.微针是一种微针.眼睛交付是通过眼睛进行的.持续释放的释放是一种持续释放.通过皮肤的路线通过皮肤.

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科学领域:

  • 生物材料科学 生物材料科学
  • 药物输送系统 药物输送系统
  • 纳米技术纳米技术

背景情况:

  • 微针 (MNs) 提供了传统注射的最小侵入性替代方案,解决了皮肤和眼部药物管理方面的挑战.
  • 各种MN设计,包括溶解,聚合物,空洞和水凝类型,可促进治疗有效载荷的控制和长时间释放.
  • 这些先进的交付平台通过减少给药频率和副作用来提高患者的遵守性.

研究的目的:

  • 审查设计用于长期作用药物输送的微针 (MN) 配方,跨越多种疾病.
  • 突出关键的设计方面,包括聚合物选择,MN几何和计算建模,以实现翻译成功.
  • 讨论MN技术的制造,监管考虑以及未来的研究方向.

主要方法:

  • 对持续药物输送的微针 (MN) 配方的文献综述.
  • 分析MN设计参数,材料选择和制造技术.
  • 对计算建模,制造可扩展性和监管途径的检查.

主要成果:

  • 不同的MN类型 (溶解,聚合物,空洞,水凝) 允许控制的,长效的治疗输送.
  • 优化的MN设计和材料选择对于实现所需的释放概况和临床影响至关重要.
  • 计算建模有助于简化MN开发以提高翻译价值.

结论:

  • 微针技术为持续的药物输送提供了一种优雅,无痛的解决方案,有可能改善患者的服药性.
  • 审慎的材料选择和精细的设计是实现全MN贴片临床潜力的关键.
  • 解决制造和监管障碍对于将先进的MN药物输送系统推向市场至关重要.