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在COVID-19之后,类风湿性关节炎的发病率增加
Juan Sebastian Marín1, Enrique A Mazenett-Granados2, Juan Carlos Salazar-Uribe3
1Health Research and Innovation Center at Coosalud EPS, Cartagena 130001, Colombia; Population Health Management Group at Coosalud EPS, Cartagena 130001, Colombia.
Autoimmunity reviews
|August 19, 2023
概括
炎症性关节炎的发生率,包括类风湿性关节炎 (RA),在COVID-19后增加,特别是在50多岁的女性中. 接种疫苗并没有防止COVID-19后炎症性关节炎的发展.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 报告显示,在COVID-19之后,炎症性关节炎的发生率增加.
- 人口特异性的效应大小需要对疾病趋势进行局部研究.
- 哥伦比亚人口数据对于了解COVID-19后的疾病发病率至关重要.
研究的目的:
- 为了评估哥伦比亚大量人口中COVID-19后的炎症性关节炎发病率趋势.
- 确定影响COVID-19后炎症性关节炎的人口和疫苗接种相关因素.
- 探索SARS-CoV-2和RA自身抗原之间的潜在分子模仿.
主要方法:
- 基于人口的回顾性队列研究,使用COOSALUD EPS注册表 (2018-2022年).
- 分析与RA相关的诊断 (ICD-10代码M059,M069,M060,等等) ) 的情况.
- 发病率 (IR) 和发病率比率 (IRR) 评估,Cox生存模型和抗原同质性的生物信息分析.
主要成果:
- 在COVID-19后,整体RA发病率显著增加 (IIR=2.01).
- 与18-30岁的女性相比,在51-60岁的女性 (HR=9.16) 中观察到风险增加.
- 接种COVID-19疫苗并没有预防炎症性关节炎;COVID-19诊断后的较长时间与较低的风险相关.
结论:
- 在COVID-19后,炎症性关节炎的确诊增加,包括RA,在第一年达到顶峰.
- 五十多岁的女性被认为是易受影响的人群.
- 需要进一步研究疫苗的有效性和将COVID-19与RA发展联系在一起的机制.
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