患有巨细胞动脉炎的患者的持续性大动脉炎
Mahmut S Kaymakci1, Nicholas A Boire2, Melanie C Bois3
1Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Autoimmunity reviews
|August 19, 2023
概括
经过胸前大动脉手术的巨细胞动脉炎 (GCA) 患者经常表现出活跃的炎症,即使是在诊断后数年. 这种慢性主动脉炎可能导致主动脉动脉瘤和剖析,增加死亡风险.
科学领域:
- 血管外科 血管外科
- 类风湿病学 类风湿病学
- 病理学 病理学 病理学
背景情况:
- 巨细胞动脉炎 (GCA) 是一种全身性血管炎,可以影响大动脉,包括大动脉.
- 胸前动脉动脉瘤和剖析是GCA患者可能发生的严重并发症.
研究的目的:
- 为了研究GCA患者的临床病理特征,这些患者接受了胸前大动脉手术.
- 确定GCA患者患有胸前动脉病理的活跃动脉炎的患病率.
- 评估胸前动脉外科手术后GCA患者的长期生存结果.
主要方法:
- 2000年至2021年间在梅奥诊所接受胸前动脉外科手术的患者的回顾性审查.
- 使用诊断码和电子文本搜索对先前的GCA诊断进行查.
- 胸前大动脉组织的病理再评估和临床病理特征的分析.
主要成果:
- 在4621名胸前大动脉手术患者中,有49人被诊断患有GCA.
- 在手术期间,在82%的GCA患者 (40/49) 中发现了活跃的风炎,GCA诊断后的中位数为6年.
- 与一般人群相比,GCA患者的标准化死亡率 (1.55) 显著增加.
结论:
- 大多数GCA患者的胸前动脉动脉炎在胸前动脉中持续存在,即使在临床缓解中.
- 动脉动脉的慢性,燃烧着的炎症是GCA中动脉动脉瘤和剖析发展的可能因素.
- 这些发现强调了长期监测GCA患者大动脉并发症的重要性.
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