通过使用FT-IR光谱技术为生物流体分析提供潜在的解决方案:光学查和诊断试验的临床影响
Luis Felipe das Chagas E Silva de Carvalho1, Thayná Melo de Lima Morais2, Marcelo Saito Nogueira3
1Departamento de Odontologia, Universidade de Taubaté, Brazil; Odontologia, Centro Universitário Braz Cubas, Brazil.
Photodiagnosis and photodynamic therapy
|August 19, 2023
概括
里埃变换红外光谱 (FT-IR) 显示了使用生物流体快速诊断疾病的巨大潜力. 增加临床医生培训和行业合作对于将这项技术纳入常规临床实践至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 里叶变换红外光谱 (FT-IR) 已经证明了在包括COVID-19在内的各种病理中快速诊断的潜力.
- 临床医生的有限认识和参与阻碍了FT-IR技术的临床转化,造成了研究人员和医疗专业人员之间的差距.
- 这种差距阻碍了基础和应用研究的整合,以直接为患者带来益处.
研究的目的:
- 突出需要增加临床医生在FT-IR光谱学方面的知识和培训.
- 强调FT-IR应用在分析血液,尿液和唾液等生物流体中的潜力,用于诊断.
- 解决临床整合所需的步骤,包括行业参与和监管考虑.
主要方法:
- 讨论FT-IR光谱的应用,用于分析生物流体 (血液,尿液,唾液) 用于诊断目的.
- 强调了血液学,传染病学,瘤学,内分泌学以及脏和消化系统诊断方面的潜在益处.
- 强调需要具有先进算法和行业合作的用户友好工具.
主要成果:
- 血液的FT-IR分析可以使血液学,感染学,瘤学和内分泌学受益.
- 通过FT-IR进行尿液分析,可以了解脏健康和泌尿系统.
- 使用FT-IR助力早期检测口腔癌和其他消化系统疾病的唾液分析.
结论:
- 分散的资金和缺乏专业培训阻碍了采用FT-IR等新技术.
- 研究,临床和行业社区之间的伙伴关系对于全球验证和翻译FT-IR技术至关重要.
- 通过合作努力克服技术验证的障碍,可以加速临床整合,使全球患者受益.
相关概念视频
01:11Applications of IR Spectroscopy: Overview
783
The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
783
01:19MALDI-TOF Mass Spectrometry
4.9K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
4.9K
01:03IR Frequency Region: Fingerprint Region
937
IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
937
01:09Infrared (IR) Spectroscopy: Overview
1.9K
When electromagnetic radiation passes through a material, atoms or molecules transition from a lower to a higher energy state by absorbing radiation corresponding to the energy difference between the two states. The absorption of infrared (IR) radiation causes transitions between vibrational energy levels in a molecule. Therefore, IR spectroscopy is a useful analytical tool for determining the molecular structure of molecules.
Different compounds display unique properties due to their...
Different compounds display unique properties due to their...
1.9K
01:25IR Spectrometers
1.2K
There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...
1.2K