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长非编码RNA和瘤微环境:乳腺癌临床应用前景

Yuxi Lei¹, Junfang He¹, Yan Tang¹

¹School of Public Health, Southwest Medical University, 1 Xianglin Road, Luzhou 646000, Sichuan, China.

Critical reviews in oncology/hematology

|August 19, 2023

概括

长非编码RNAs (LncRNAs) 在乳腺瘤微环境 (TME) 中起着至关重要的作用,影响癌症的进展和转移. 了解TME中的LncRNA机制为乳腺癌治疗提供了潜在的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一种遗传学.

背景情况:

乳腺癌是全球领先的癌症,转移是死亡的主要原因.
瘤微环境 (TME) 通过复杂的细胞相互作用显著影响瘤的生长,进展和转移.
长非编码RNAs (LncRNAs) 越来越多地被认为参与塑造TME并影响瘤发生.

研究的目的:

审查乳腺癌TME中的LncRNAs的特征和功能.
阐明TME中的LncRNAs驱动乳腺癌发展和转移的机制.
确定LncRNAs作为潜在的生物标记物或临床应用的治疗点.

主要方法:

对乳腺癌TME中LncRNAs研究的文献综述.
对LncRNA与免疫细胞,非免疫细胞和TME内的细胞外基质相互作用的分析.
综合关于乳腺癌进展的LncRNA介导机制的当前知识.

主要成果:

LncRNAs是乳腺癌TME的组成部分,调节其各个元素.
LncRNAs通过与免疫细胞,树皮细胞和细胞外基质的相互作用来影响乳腺癌的进展和转移.
特定的LncRNAs显示出作为诊断或预后生物标志物的潜力.

结论:

LncRNAs是乳腺癌TME的关键调节者.
在TME中准LncRNA功能为新型乳腺癌疗法提供了一个有前途的战略.
对LncRNA机制的进一步研究可以改善乳腺癌患者的临床结果.

关键词:

乳腺癌是什么? 乳腺癌是什么免疫细胞是一种免疫细胞.在 LncRNAs 中.非免疫细胞的细胞.瘤微环境中的微环境

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