在免疫抑制患者中传播性组织等离子体病的患者成功地接受了isavuconazole治疗
Anita D Sircar1, Mai-Chi N Tran2, Sagar A Vaidya3
1Infectious Diseases, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA asircar@yahoo.com.
BMJ case reports
|August 19, 2023
概括
当标准疗法失败时,免疫受损患者的传播性组织等离子体病被isavuconazole成功治疗. 这一案例突出了伊萨夫可纳作为耐火性真菌感染的潜在替代品.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 血清性质是一种在某些地区特有的真菌感染,由*Histoplasma capsulatum*引起.
- 标准的治疗方法包括安福特里辛B和伊特拉可纳.
- 免疫功能低下的患者患传播性疾病的风险更高.
研究的目的:
- 报告一个患有风湿性关节炎的患者传播性基因质的病例,该患者接受了用甲状腺和infliximab治疗.
- 为了评估 isavuconazole 的疗效和安全性,在一线和二线治疗失败的患者中.
- 审查现有的关于伊萨武可纳用于基质体和母细胞菌根症的文献.
主要方法:
- 一个患有散布性基因质菌症的病人的病例报告.
- 关于伊萨武可纳治疗血清和芽细胞菌的文献综述.
- 对免疫功能低下患者治疗结果的分析.
主要成果:
- 患者经历了治疗失败和标准疗法 (伊特拉科纳和脂质体安二乙) 的不良反应.
- 伊萨夫可纳与类固醇结合导致完全康复.
- 文献综述发现了伊萨武可纳在组织等离子体和母细胞菌的其他成功用途,包括在严重免疫功能低下的个体中.
结论:
- 当一线和二线疗法无效或禁用时,伊萨夫可纳可以成为对基质质体病的可行的治疗选择.
- 该药物在治疗免疫功能低下患者的真菌感染方面表现有前途,包括那些服用TNF-α对抗剂的患者.
- 需要进一步的研究,以确定伊萨武可纳在治疗特有真菌菌的作用.
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