一个系统的图表审查的药理干预在克洛扎诱导过的患者的药理干预
Emre Mutlu1, Elçin Özçelik Eroğlu1, F Özlem Coşkun1
1Department of Psychiatry, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Schizophrenia research
|August 19, 2023
概括
用阿特罗平或热皮卡米德的口水有效治疗克洛扎诱导的唾液过多 (CIH). 切换药物改善了持续性CIH,没有报告严重不良事件. 需要进行进一步的研究.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 克洛扎诱导的唾液过多 (CIH) 是克洛扎治疗的常见副作用.
- 对CIH有效的管理策略对于患者的坚持和生活质量至关重要.
研究的目的:
- 评估各种药物的疗效和耐受性,用于治疗克洛扎诱导的唾液过多 (CIH).
- 评估CIH的第一阶段和第二阶段药理干预措施的有效性.
主要方法:
- 追溯审查了2010年至2022年间接受克洛扎宾治疗的161名住院患者的病历.
- 主要结局指标是枕头上的湿贴 (DWP) 直径的百分比变化,以量化CIH改善.
- 评估的药物包括使用氨酸硫酸和热胺滴滴的口水,口服阿米林和阿米苏尔普里德.
主要成果:
- 克洛扎诱导的唾液过多 (CIH) 在42%的患者中发生.
- 第一阶段的治疗方法 (热皮卡米德,阿特罗宾,阿米特利普提林) 显著降低了DWP,平均为33%.
- 第二阶段的药物,包括阿米苏普里德,在持续的病例中进一步减少了DWP的中位数42% ,没有严重的不良事件.
结论:
- 用热素或热胺滴滴的口水应用是一种耐受且有效的治疗 clozapine 诱导的唾液过多 (CIH).
- 切换到替代药物是有效的管理持久性CIH.
- 需要进一步的研究来探索CIH,克洛扎水平和临床结果之间的联系.
相关概念视频
Drug Therapy
68
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
68
Psychosis: Goals of Pharmacotherapy
165
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
165
Antipsychotic Drugs: Typical and Atypical Agents
246
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
246
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
332
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
332
Psychosis and Antipsychotic Drugs: Overview
327
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
327
Antidepressant Drugs: MAOIs and Other Agents
272
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
272


