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瘤的微环境,组织蛋白修饰,以及由髓状细胞衍生的抑制细胞

Xinyu Tian¹, Ting Wang², Han Shen³

¹Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.

Cytokine & growth factor reviews

|August 19, 2023

概括

髓衍生抑制细胞 (MDSC) 中的质蛋白修饰是瘤微环境 (TME) 中的关键表观遗传调节者. 了解这些修改为逆转瘤诱导的免疫抑制提供了新的策略.

科学领域:

免疫学免疫学免疫学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
癌症生物学癌症生物学

背景情况:

骨髓系衍生抑制细胞 (MDSC) 在瘤微环境 (TME) 中至关重要,通过免疫抑制促进免疫逃生.
MDSC扩张和功能与TME信号通路有关,但表观遗传调节者仍未得到充分研究.

研究的目的:

审查基因组修饰在MDSC分化和TME内的功能中的作用.
探索针对基因组修饰的表观遗传干预措施,以抵消MDSC介导的免疫抑制.

主要方法:

文献综述,重点关注MDSC中的基因组修饰及其修饰剂.
分析TME对MDSC表观遗传调节的影响.
检查当前调节基因组修饰的表观遗传疗法.

主要成果:

基斯顿修饰显著影响TME内的MDSC差异化和功能.
在MDSCs中,TME积极塑造组织蛋白修饰模式.
针对基因组修饰的表观遗传干预在逆转MDSC诱导的免疫抑制方面表现有前途.

结论:

基因组基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因.
向激素修饰是克服瘤诱导免疫抑制的可行策略.
需要进一步的研究,以充分阐明基因组修饰在MDSCs中的作用.

关键词:

表观遗传疗法是一种表观遗传疗法.基质子的修改基质子的修改来自骨髓细胞的抑制细胞.瘤微环境是一个微环境.

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