牛皮患者的甲状腺异常:患病率和严重程度的关联
Luiza de Castro Fernandes1, Ana Carolina Belini Bazan Arruda2, Lisa Gava Baeninger2
1Department of Internal Medicine, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Anais brasileiros de dermatologia
|August 19, 2023
概括
这项研究发现,巴西牛皮患者甲状腺异常的患病率很高. 然而,甲状腺问题和牛皮的严重程度或治疗之间没有发现直接联系.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
- 临床研究 临床研究
背景情况:
- 牛皮是一种慢性炎症状况,与各种并发症有关.
- 牛皮和甲状腺异常之间的关联是正在进行的研究和假设的主题.
- 了解这些联系对于全面的患者管理至关重要.
研究的目的:
- 为了确定被诊断为牛皮的巴西患者甲状腺异常的患病率.
- 调查甲状腺功能障碍和牛皮严重程度,牛皮关节炎和免疫生物治疗之间的潜在关联.
- 通过将研究结果与现有的国际文献进行比较,将研究结果置于背景中.
主要方法:
- 一项观察性研究分析了2018年1月至2019年12月期间161名符合条件的巴西牛皮患者的临床和实验室数据.
- 用甲状腺刺激激素 (TSH),自由甲状腺素 (FT4) 和自身抗体 (抗TPO,抗TG) 来评估甲状腺功能.
- 牛皮的严重程度通过牛皮区域和严重程度指数 (PASI) 进行测量,患者根据牛皮关节炎的存在和治疗类型进行分类.
主要成果:
- 在研究队列中观察到甲状腺异常 (28.57%) 和甲状腺功能低下 (14.91%) 的显著患病率.
- 在甲状腺异常和PASI评分 (p=0.8),牛皮关节炎 (p=0.87) 或免疫生物治疗 (p=0.13) 之间没有发现统计学意义上的关联.
- 与基于文献的对照组 (p<0.0001) 相比,在甲状腺功能低下的患病率上发现了显著的差异.
结论:
- 这项研究强调了巴西牛皮患者中甲状腺异常的显著流行率.
- 尽管患病率很高,但甲状腺功能障碍与关键的牛皮病标志物或该队列中的治疗方法之间没有直接相关性.
- 缺乏同中心对照组是一个局限性,这表明需要进一步研究和强大的控制.
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