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肠道微生物组与患有囊性纤维化症的婴儿的生长之间的关联

A R Deschamp¹, Y Chen², W F Wang²

¹Indiana University School of Medicine, Riley Children's Hospital, 340 10th Street, Indianapolis, IN 46202, United States of America.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

|August 19, 2023

概括

患有囊性纤维化 (CF) 的婴儿在美国和澳大利亚之间表现出明显的肠道微生物群差异. 在CF婴儿中,营养不良和抗生素使用与减少短链脂肪酸的产生有关.

科学领域:

微生物学微生物学
儿科儿科儿科
胃肠病学胃肠病学

背景情况:

囊性纤维化 (CF) 改变了胃肠道,导致营养不良和肠道微生物组的变化.
这些微生物组变化与CF患者的生长,炎症和呼吸系统问题有关.
了解这些肠道微生物组的变化对于未来CF的营养管理策略至关重要.

研究的目的:

在不同地理位置 (美国与澳大利亚) 调查和比较患有囊性纤维化 (CF) 的婴儿的肠道微生物组组成和多样性.
确定肠道微生物丰富度与年龄,抗生素预防,营养不良和母乳养等因素之间的关联.
探索微生物组变化的功能影响,特别是关于短链脂肪酸 (SCFA) 生产.

主要方法:

在美国和澳大利亚的四个地点,从12个月内患有CF的婴儿收集了纵向便样本.
使用16S rRNA基因测序来分析肠道微生物组合.
用通用线性混合模型来评估微生物丰富度与临床因素之间的关联,包括营养不良和抗生素使用.

主要成果:

与美国 (US-CF) 相比,澳大利亚的CF婴儿 (AUS-CF) 表现出较低的肠道微生物α多样性.
在AUS-CF的婴儿中,蛋白质细菌的相对丰度较高,与抗生素预防有关.
CF 婴儿的营养不良与乳球菌枯竭有关,并预测SCFA 生产代谢通路的减少.

结论:

美国和澳大利亚的CF婴儿之间存在肠道微生物组合和多样性的显著差异.
发现肠道微生物多样性与该队列的线性生长没有直接相关.
营养不良,抗生素预防和CF婴儿中SCFA发酵减少之间的相互作用需要进一步研究其对肠道健康的影响.

关键词:

囊性纤维化症是什么我们的肠道微生物组.婴儿的成长婴儿的成长.

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