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用molnupiravir治疗的患者住院治疗:对行政数据的回顾性研究
Girish Prajapati1, Amar Das1, Yezhou Sun1
1Merck & Co, Inc, Rahway, New Jersey, USA.
Clinical therapeutics
|August 19, 2023
概括
在高风险成年人中,用于COVID-19的Molnupiravir治疗显示出较低的住院率. 大多数患者都有风险因素,许多人服用相互作用的药物,但严重的结果是罕见的.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 莫尔努皮拉维尔 (Molnupiravir) 是一种口服抗病毒药物,用于高风险成年人治疗轻度至中度的COVID-19.
- 紧急使用授权强调其在控制严重疾病进展中的作用.
研究的目的:
- 为了描述接受门诊molnupiravir的成年患者.
- 评估健康结果,包括住院治疗,后期治疗.
主要方法:
- 使用HealthVerity数据库索赔的回顾性队列研究.
- 从2021年12月到2022年4月收集的数据.
- 在molnupiravir索赔后28天内评估住院和医疗保健利用情况.
主要成果:
- 26,554名患者接受治疗;71.1%的患者年龄≥50岁,58.9%为女性.
- 79.1%的人患有严重COVID-19的≥1个危险因素 (例如高血压,免疫抑制).
- 整体住院人数为3.3%,COVID-19为1.7%;ICU入院和通风不常见.
结论:
- 大多数molnupiravir接受者都有风险因素和潜在的药物相互作用.
- 住院治疗后不常见,重症监护和通风率低.
- 由于研究的局限性,无法得出关于molnupiravir有效性的结论.
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