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自组合和纳米银化物在重矿化早期膜病变:随机对照临床试验

Sara M Atteya¹, Hala A Amer², Susan M Saleh²

¹Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Champollion St., Azarita, 21527, Alexandria, Egypt. sara.atteya@alexu.edu.eg.

BMC oral health

|August 19, 2023

概括

自组合 (P11-4) 和纳米银化物 (NSF) 在减少牙白斑病变 (WSLs) 方面表现有前途. 虽然这两种药物都改善了病变得分,但它们的有效性在12个月内与化 (NaF) 相当.

科学领域:

牙科的生物材料.
牙损伤预防牙损伤的预防
纳米技术在牙科中的应用

背景情况:

纳米粒子和再生生物矿物化代表了预防的新方法.
这项研究研究了自组合 (P11-4),纳米银化物 (NSF) 和化 (NaF) 对永久牙白斑病变 (WSL) 的重矿化潜力.

研究的目的:

评估和比较P11-4,NSF和NaF在永久牙中的WSL上的重矿效果.
用标准化临床指数和诊断工具评估损伤活动和矿物质含量的变化.

主要方法:

66名患有WSL的年轻人 (ICDAS代码1或2) 被随机分配到三个组:P11-4,NSF或NaF.
临床评估 (ICDAS,Nyvad分数) 和DIAGNOdent读数在基线和1,3,6和12个月后被记录下来.
统计分析包括千二测试,麦克纳马测试和多层次二进制后勤回归来比较治疗效果.

主要成果:

在3个月和6个月的组之间观察到ICDAS得分变化的显著差异 (p=0.005).
P11-4组表现出ICDAS得分减少的最大增加 (12个月后54.5%),以及不活跃病变的最高百分比.
与NaF相比,多级二进制物流回归表明P11-4和NSF的ICDAS分数没有显著减少.

结论:

无论是P11-4还是NSF漆,都有效地降低了ICDAS评分,牙活动以及永久牙中WSL的DIAGNOdent读数.
尽管观察到改善,但ICDAS评分的整体变化在P11-4/NSF和NaF治疗之间没有显著差异.

关键词:

诊断师是一个诊断师.这就是ICDAS的意思.纳米白银化物是什么意思在P11-4中,P11-4是指P11-4中,P11-4是指自组装的自组合.化和化的使用方法白斑病变是白斑的病变.

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