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目标沉默和重新激活的循环是灵长类动物前额和皮层中复杂的问题解决的基础
Kei Watanabe1,2,3, Mikiko Kadohisa4,5, Makoto Kusunoki4,5
1Department of Experimental Psychology, University of Oxford, OX1 3SR, Oxford, UK. kei_watanabe@fbs.osaka-u.ac.jp.
Nature communications
|August 19, 2023
概括
工作记忆 (WM) 可能不依赖于不断的神经发射. 相反,像前额叶皮层 (PFC) 和后额叶皮层 (PPC) 这样的大脑区域使用动态沉默和重新激活记忆.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 经典理论提出了持续的神经激发工作记忆 (WM).
- 新出现的证据表明,活动沉默的状态有助于WM.
- 人类神经成像表明,在WM中注意力前景/背景切换.
研究的目的:
- 研究工作记忆维护和检索的细胞机制.
- 检查前额叶皮层 (PFC) 和后额叶皮层 (PPC) 神经元在复杂的问题解决任务中的作用.
- 在神经表征中区分持续触发和活动静止状态.
主要方法:
- 在复杂的问题解决任务期间,记录了子在PFC和PPC中的神经元活动.
- 子在多个试验周期中搜索并重新访问目标位置.
- 分析了与目标位置相关的持续活动,沉默和重新激活的神经发射模式.
主要成果:
- 在整个试验中,在PFC或PPC神经元中没有发现持续的目标位置代码.
- 观察到及时的目标沉默和重新激活,随后持续状态直到响应.
- PFC表示显示了更完整的目标跟踪,包括过去和未来的选择,表明前景/背景过渡.
结论:
- 工作记忆的维护和检索在试验中依赖于动态的神经元状态,而不是连续的持续发射.
- 不同的神经元状态 (沉默,重新激活) 之间的相互作用支持WM表示.
- 在整合WM的时间信息方面,PFC起着至关重要的作用,超越了当前的试验.
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