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Updated: Jul 18, 2025

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奥图林在炎症和感染期间保护肠道上皮细胞免受亡

Lien Verboom1,2, Christopher J Anderson1,2,3, Maude Jans1,2

  • 1VIB Center for Inflammation Research, 9052, Ghent, Belgium.

Cell death & disease
|August 19, 2023
PubMed
概括

肠道细胞中具有线性结合特异性 (OTULIN) 的OTU二维基因酶缺乏会增加对结肠炎和沙门氏菌感染的易感性. 这是由于TNF信号受损而引起的,导致上皮细胞死亡和肠道屏障功能受损.

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