晚年抑郁症中的大脑认知关系:结构磁共振成像研究的系统审查
Tulip Marawi1,2, Nicholas J Ainsworth1,3, Peter Zhukovsky2
1Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Translational psychiatry
|August 19, 2023
概括
晚年抑郁症 (LLD) 通常涉及认知障碍,可能表明轻度认知障碍 (MCI). 大脑成像研究将减少的前额/部灰质和白质完整性与LLD和LLD+MCI的认知缺陷联系起来.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 晚年抑郁症 (LLD) 经常与认知障碍同时发生.
- 相当一部分LLD患者符合轻度认知障碍 (MCI) 的标准,这是阿尔茨海默氏症痴呆症的潜在前体.
- 连接LLD,MCI和认知衰退的精确大脑机制和变化仍然不够理解.
研究的目的:
- 在LLD和LLD+MCI中系统地审查大脑认知关系.
- 在这些患者群体中确定与认知障碍相关的特定神经回路.
- 综合神经成像研究的发现,研究LLD和LLD+MCI中的结构性大脑变化.
主要方法:
- 在MEDLINE,PsycINFO,EMBASE和Web of Science数据库中进行系统的文献搜索.
- 包括评估认知并使用T1加权成像 (灰质) 或扩散加权成像 (白质完整性) 的研究.
- 由于51篇确定文章的异质性,对发现的描述性综合.
主要成果:
- 额头和部区域灰质厚度/体积的减少与LLD的认知障碍有关.
- 白质完整性的广泛减少与LLD和LLD+MCI的认知缺陷有关.
- 后带皮带白质完整性与执行功能和处理速度障碍特别相关,比记忆更重要.
结论:
- 尽管有研究的局限性,但证据表明LLD和LLD+MCI中的特定大脑结构变化.
- 未来的研究需要更大,多样化的样本和先进的统计模型来澄清大脑认知联系.
- 进一步的研究对于理解神经退行性途径和开发有针对性的干预措施至关重要.
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