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脊髓交叉点作为脊髓截面面积的参考:在部位置的验证

Sandrine Bédard¹, Maxime Bouthillier², Julien Cohen-Adad^3,4,5,6

¹NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada. sandrine.bedard@polymtl.ca.

Scientific reports

|August 19, 2023

概括

这项研究发现,作为脊髓横截面积 (CSA) 测量的参考点,使用脊髓横截面 (PMJ) 与传统的脊椎方法一样可靠,即使是部运动. 这为脊髓缩评估提供了一个有价值的替代方案.

科学领域:

神经成像和神经科学神经成像和神经科学
生物标志物开发生物标志物开发
脊髓成像脊髓成像

背景情况:

脊髓横切面积 (CSA) 是评估神经疾病中脊髓缩的关键MRI生物标志物.
传统的CSA测量依赖于脊椎水平,这引入了由于不可靠的脊柱水平预测而导致的显著变化.
桥髓结 (PMJ) 已被提议作为一种内在的神经解剖学参考,以提高CSA测量可靠性.

研究的目的:

为了评估是否使用桥结节 (PMJ) 作为参考,与脊椎水平相比,减少脊髓横截面积 (CSA) 测量的变化.
评估PMJ方法在不同部位置 (屈曲,中性,延伸) 的可靠性.

主要方法:

十名参与者接受了3T MRI T2w同位素扫描 (0.6 mm3) 在三个部位置.
自动计算脊髓细分,脊椎标记,PMJ标记和CSA的自动计算.
手动标记脊柱段进行比较.

主要成果:

部位置的CSA平均变化系数与PMJ (3.99±2.96%),手动脊柱段 (4.02±3.01%) 和圆盘 (4.46±3.10%) 方法相似,没有统计意义.
虽然PMJ方法的可靠性略高于基于磁盘的CSA计算方法,但在统计学上并不显著.
在CSA测量的变化是可比的跨方法,即使在不同的部延伸.

结论:

脊柱骨髓结 (PMJ) 作为一个可靠的替代参考,用于估计脊髓横截面积 (CSA).
该PMJ方法提供与传统方法相比可靠性,特别是当基于磁盘的方法具有挑战性时 (例如,合磁盘).
这种方法对于在神经退行性和创伤性疾病中一致评估脊髓缩是有价值的.

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