与乳腺癌患者的三级淋巴体结构相关的基因组特征和临床结果
Liye Wang1, Shuai Gong1, Lina Pang1
1Department of Oncology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, People's Republic of China.
Scientific reports
|August 19, 2023
概括
对于三级淋巴体结构 (TLSs) 的新型9基因特征预测乳腺癌 (BRCA) 患者的结果更好. 这种TLS签名也表明免疫治疗的反应改善和有利的免疫微环境.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 在固体瘤中,三级淋巴体结构 (TLS) 对预后和免疫治疗反应至关重要.
- 与TLS相关的基因特征在乳腺癌 (BRCA) 的预后作用仍在争论中.
- 癌症基因组图谱 (TCGA) 为研究这种签名提供了宝贵的资源.
研究的目的:
- 在乳腺癌中识别和验证TLS相关的基因特征.
- 评估这个签名对整体存活时间 (OS) 的预后价值.
- 探索TLS签名与分子亚型,免疫微环境和瘤突变负担 (TMB) 之间的关系.
主要方法:
- 使用TCGA-BRCA数据集 (n=866) 来识别一个9基因TLS签名.
- 使用METABRIC队列验证了签名.
- 进行了多变量分析,并构建了一个用于风险预测的nomogram.
- 分析了与分子亚型,免疫细胞透和TMB的相关性.
主要成果:
- 一个9基因的TLS签名被识别和验证,显示高TLS患者的生存状况明显改善.
- TLS签名是OS的独立预后指标.
- 高TLS特征与免疫治疗的益处相关,抑制增殖途径,低TP53突变率,以及免疫细胞 (B细胞,CD8+ T细胞,CD4+ T细胞,M1巨细胞) 的透率增加.
结论:
- 已识别的9基因TLS特征是预测乳腺癌预后的有希望的生物标志物.
- 这种特征有效地区分免疫微环境,并预测BRCA患者的免疫治疗反应.
- 这些发现支持将TLS签名纳入乳腺癌管理的临床决策.
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