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内分泌干扰化合物和新陈代谢重编程在乳腺癌中

Cassandra Winz^1,2, Wei-Xing Zong^1,3, Nanjoo Suh^1,3

¹Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.

Journal of biochemical and molecular toxicology

|August 20, 2023

概括

内分泌干扰化学物质 (EDC) 模仿激素,可能增加乳腺癌风险. 本综述探讨EDC如何改变细胞代谢,促进癌症的发展.

科学领域:

环境健康环境健康
内分泌学在内分泌学.
在瘤学瘤学.

背景情况:

内分泌干扰化学物质 (EDC) 是干扰激素信号的环境污染物.
雌激素EDC与乳腺癌风险增加有关,但机制尚不清楚.
癌细胞表现出改变的新陈代谢以快速增殖.

研究的目的:

审查最近关于EDC及其在乳腺癌中的作用的发现.
探索EDC如何诱导乳腺癌发展中的代谢重编程.

主要方法:

对EDC,内分泌干扰和癌症代谢研究的文献综述.
专注于代谢分析,以了解途径的改变.
综合关于EDC诱导的代谢变化的当前知识.

主要成果:

EDCs可以调节细胞信号通路的失调.
通过EDCs进行代谢重编程可能会促进乳腺癌的进展.
代谢学揭示了受EDCs影响的关键途径.

结论:

EDCs代表着与乳腺癌相关的重大环境威胁.
代谢重编程是EDCs促进乳腺癌的一个关键机制.
使用代谢学进行进一步的研究对于理解和减轻EDC风险至关重要.

关键词:

双醇是一种双醇.乳腺癌乳腺癌乳腺癌破坏内分泌的化合物破坏内分泌的化合物代谢生物组的代谢生物组甲酸甲酸是一种泽拉诺尔是什么意思

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