环境和职业支气管炎消灭:新的现实
Sergey S Gutor1, Robert F Miller1, Timothy S Blackwell2
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
EBioMedicine
|August 20, 2023
概括
环境/职业支气管炎消灭症 (BO) 通常会微妙地表现为运动性呼吸不良. 现代病例显示小气道重塑和炎症,需要考虑在有毒素暴露史的患者.
科学领域:
- 肺部医学 肺部医学
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
背景情况:
- 环境/职业支气管炎消灭症 (BO) 越来越多地被诊断为患有惰呼吸道症状的患者.
- 典型的表现缺乏急性,高水平的空气中毒素暴露的历史.
- 劳动性呼吸障碍是一个常见的症状,通常与非诊断的初步评估.
研究的目的:
- 描述当代环境/职业BO的临床,病理和放射性特征.
- 为了突出这一条件的诊断考虑.
主要方法:
- 在过去二十年中,对被诊断患有环境/职业性BO的病例进行了审查.
- 分析临床表现,肺活检结果和放射性评估.
主要成果:
- 现代BO病例经常表现出狭窄性支气管炎现型,具有小呼吸道重塑和淋巴细胞炎症.
- 相关的发现包括高血压肺内血管架构重塑,膜纤维延伸症和膜加厚.
- 肺活检揭示了远端肺区的异常.
结论:
- 环境/职业BO诊断应考虑在患有亚急性劳动性呼吸障碍和长期/反复暴露于环境毒素的病史的患者.
- 未来的研究应该专注于不太侵入的诊断方法和新型治疗/预防药物.
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