针对癌症治疗中的元素的向药物递送系统:迄今为止的故事
Huan Tian1, Feng Zhao1, Qing-Rui Qi2
1Xi'an Hospital of Traditional Chinese Medicine, Xi'an 710021, PR China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|August 20, 2023
概括
传统中医药的Elemene (ELE) 显示出抗癌的前景,但面临着交付方面的挑战. 基于纳米材料的有针对性的传递系统增强了ELE.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 素 (ELE) 是一种来自中国传统医药 (TCM) 的广谱抗癌剂.
- ELE的毒性较低,但其生物利用性不佳,半衰期短,体内向性弱.
- 基于纳米材料的向药物递送系统为ELE的局限性提供了可行的解决方案.
研究的目的:
- 审查Elemene作为辅助抗瘤治疗的临床应用.
- 总结Elemene和基于Elemene的组合策略的抗瘤机制.
- 综合审查Elemene与先进的向药物递送系统的组合.
主要方法:
- 对Elemene作为辅助治疗的临床研究的文献综述.
- 对Elemene的抗瘤机制和组合策略的研究分析.
- 与Elemene结合的向药物输送系统的系统总结.
主要成果:
- 基于Elemene的组合策略在提高疗效,减少不良反应,改善患者的生活质量和免疫功能方面表现有前途.
- 埃莱门的抗瘤机制包括诱导热,铁,衰老,调节m6A修饰,抑制华堡效应,诱导细胞亡和细胞循环停止.
- 有针对性的输送系统 (被动,活跃,刺激反应,代码输送) 显著提高了ELE的生物可用性,向性,受控释放,有效性,并减少了不良反应和多药性耐药性 (MDR).
结论:
- 作为一种抗癌剂,Elemene具有显著的潜力,特别是在与其他疗法相结合时.
- 有针对性的药物输送系统对于克服Elemene的药理动力学和生物分发挑战至关重要.
- 像Elemene这样的TCM与先进的向传递系统的结合代表了癌症治疗未来有希望的方向.
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