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Updated: Jul 18, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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探索基纳素基支架的第6位和第7位导致对RIPK2/3激酶的选择性和强度的变化

Mbilo Misehe1, Marika Matoušová2, Alexandra Dvořáková2

  • 1Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo Nam. 2, 166 10, Prague 6, Czech Republic; Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030/8, 128 43, Prague 2, Czech Republic.

European journal of medicinal chemistry
|August 20, 2023
PubMed
概括

针对受体相互作用蛋白激酶2和3 (RIPK2和RIPK3) 的新型quinazoline衍生物在细胞模型中显示出强大的抑制作用. 这些化合物表现出良好的稳定性和选择性,具有治疗炎症性疾病和癌症的潜力.

关键词:
炎症 炎症是一种炎症.激酶抑制剂 激酶抑制剂这是一个NOD NOD.基纳林衍生物 基纳林衍生物在RIPK2中使用RIPK2.在RIPK3中使用RIPK3.

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