Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Boosting Vaccine Research: The 16-Year Journey of TRANSVAC Vaccine Infrastructure.

Vaccines·2025
Same author

Lipid A heterogeneity and its role in the host interactions with pathogenic and commensal bacteria.

microLife·2023
Same author

Nanoflow LC-MS Method Allowing In-Depth Characterization of Natural Heterogeneity of Complex Bacterial Lipopolysaccharides.

Analytical chemistry·2021
Same author

Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation.

Pharmaceutics·2021
Same author

Shortening the Lipid A Acyl Chains of <i>Bordetella pertussis</i> Enables Depletion of Lipopolysaccharide Endotoxic Activity.

Vaccines·2020
Same author

Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of <i>Bordetella pertussis</i> lipid A.

The Journal of biological chemistry·2019

相关实验视频

Updated: Jul 18, 2025

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

1.8K

基于外膜囊泡的鼻内疫苗.

Peter Van der Ley1, Virgil Ejc Schijns1

  • 1Intravacc BV, 3721 MA Bilthoven, the Netherlands.

Current opinion in immunology
|August 20, 2023
PubMed
概括

粘膜疫苗,特别是使用外膜囊泡 (OMV) 进行鼻内注射的疫苗,与传统疫苗相比,对粘膜感染提供更好的保护. 这种方法引起了局部和全身免疫力,有效地阻止疾病的进入和传播.

科学领域:

  • 免疫学 免疫学 免疫学
  • 疫苗学 疫苗学 疫苗学
  • 生物技术是生物技术.

背景情况:

  • 粘膜疫苗非常适合通过粘膜组织 (口腔,鼻腔,肺,肠道,泌尿器官) 进入的感染.
  • 它们诱导局部 (分泌IgA) 和全身免疫,可能通过共同的粘膜免疫系统保护遥远的粘膜部位.
  • 下一代粘膜疫苗可能会通过阻断粘膜表面的感染和传播,超过肠道疫苗.

研究的目的:

  • 审查外膜囊泡 (OMVs) 的特征和临床潜力,作为粘膜疫苗输送平台.
  • 突出鼻腔内输送的优点,准与鼻腔相关的淋巴组织进行免疫.
  • 讨论OMV用于同类细菌抗原和来自病毒,寄生虫和癌症的异质抗原的使用.

主要方法:

  • 对OMV作为疫苗平台的现有文献的审查.
  • 对研究粘膜接种疫苗的研究分析,特别是鼻内接种.
  • 检查OMV应用程序的细菌以外的各种抗原.

主要成果:

  • 外膜囊泡 (OMVs) 是通过粘膜路径传递抗原的多功能平台.
  • 使用OMV的鼻腔内接种疫苗对于向粘膜相关的淋巴组织特别有希望.
  • 可以设计OMV来携带各种病原体和疾病的抗原,包括病毒,寄生虫和癌症.

更多相关视频

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

2.6K
Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
10:39

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

Published on: June 25, 2015

12.7K

相关实验视频

Last Updated: Jul 18, 2025

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

1.8K
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
08:07

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

2.6K
Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
10:39

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

Published on: June 25, 2015

12.7K

结论:

  • 工程化OMVs代表着一个有前途的疫苗平台,用于粘膜,特别是鼻内输送.
  • 这一战略对开发下一代疫苗具有重大潜力,可诱导强大的局部和全身免疫力.
  • OMVs为亲肠道疫苗接种提供了可行的替代方案,具有阻断粘膜表面感染和传播的能力.