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在急性肺栓塞患者中,癌症的预测因素
Gonçalo Felix1, Ester Ferreira2, Ana Ribeiro2
1Faculdade de Medicina da Universidade do Porto, Portugal.
在急性肺栓塞 (PE) 患者中,D-二聚物水平升高显著增加未被诊断的癌症的风险. 超过15.0微克/毫升的D-二聚物水平将使未来癌症诊断的可能性增加一倍以上.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 血液学 血液学 血液学
背景情况:
- 急性肺栓塞 (PE) 可能是潜在癌症的副瘤表现.
- 识别PE患者的隐性癌症对于及时诊断和治疗至关重要.
- 之前的研究并没有专注于在急性PE患者中确定隐性癌症的预测因子.
研究的目的:
- 在被诊断为急性肺栓塞的患者中确定隐性癌症的预测因素.
- 调查D-二聚物水平是PE患者潜在癌症的预测指标的假设.
主要方法:
- 住院急性PE患者的回顾性分析.
- 排除标准包括18岁以下的患者,非肺静脉栓塞,慢性栓塞或缺乏急性PE确认.
- 后勤回归和多变量模型被用于识别并发癌症的预测因素.
主要成果:
- 该研究包括562名患者;22.4%的患者患有已知的癌症,8.4%的患者在2年内被诊断出癌症,69.2%的患者在2年内没有癌症诊断.
- 升高的D-二聚物水平与已知的癌症独立相关.
- D-二元水平>15.0微克/毫升预测了未来的癌症诊断 (OR=2.10),贫血也预测了未引起的PE中未知的癌症 (OR=2.13).
结论:
- 患有D-二聚物水平>15.0μg/mL的患者在2年内患癌症的风险增加了两倍以上.
- D-二聚合物水平可以帮助临床医生识别患有隐性癌症风险较高的PE患者.
- 贫血也是未知癌症的预测因子在没有引起的PE患者.
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