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异常小气道功能指标的风险因素 鼻息肉患者 患有喘和没有喘的患者
Jing Guo1,2,3, Jianwei Wang1,2,3, Xinjun Xu1,2,3
1Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
International archives of allergy and immunology
|August 20, 2023
概括
喘和过敏性鼻炎增加了慢性鼻炎与鼻息肉 (CRSwNP) 患者中小呼吸道功能障碍 (SAD) 的风险. 年龄和血液中乙酸氨基是喘CRSwNP患者SAD的关键风险因素.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 小呼吸道功能障碍 (SAD) 与非喘性慢性鼻炎与鼻 (CRSwNP) 的2型炎症有关.
- 患有或没有喘的CRSwNP患者中小气道功能异常的危险因素尚不清楚.
研究的目的:
- 确定有或没有喘的CRSwNP患者中异常小气道功能指标的危险因素.
- 为了比较喘和非喘CRSwNP患者之间的小气道功能.
主要方法:
- 对41名喘患者和109名非喘CRSwNP患者的回顾性分析.
- 组间临床特征的比较.
- 小气道功能与临床参数的相关性分析.
- 确定每个组中小型气道指标的独立风险因素.
主要成果:
- 喘性CRSwNP患者的小气道功能显著降低,与非喘性CRSwNP患者 (9.17%) 相比,SAD的患病率更高 (65.85%).
- 在喘性CRSwNP患者中,年龄和血中乙氨基酸百分比是减少FEF50% %pred和FEF25-75% %pred的独立风险因素,以及FEF75% %pred的年龄.
- 过敏性鼻炎是非喘CRSwNP患者FEF50%%pred,FEF75%%pred和FEF25-75%%pred降低的独立风险因素.
结论:
- 喘显著影响CRSwNP患者的小气道功能.
- 年龄,血液中乙酸细胞和过敏性鼻炎是CRSwNP中小呼吸道功能障碍的关键风险因素.
- 临床医生应关注这些风险因素,以预防CRSwNP患者的SAD.
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