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莫克西德克丁的大量药物管理可以加速非洲的氏球菌病的消除吗?

Klodeta Kura^1,2, Philip Milton^1,2, Jonathan I D Hamley^1,2

¹London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London W2 1PG, UK.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

|August 20, 2023

概括

在非洲,每年一次的艾弗梅克丁大规模药物注射 (MDA) 可能无法消除Onchocerca volvulus传播 (EoT). 两年一度的莫克西德MDA显示,有可能将EoT的时间缩短一半,并且可能是hyperendemic地区的关键.

科学领域:

热带医学热带医学
寄生虫学的寄生虫学
数学的建模数学建模

背景情况:

在非洲,每年一次的艾弗梅克丁大规模药物管理 (MDA) 可能不足以消除Onchocerca volvulus传播 (EoT).
在临床试验中,莫西德克丁在长时间的微粒细胞清除方面表现出优异的优异性,与伊弗梅克丁相比.

研究的目的:

使用EPIONCHO-IBM模型,比较使用ivermectin与moxidectin MDA实现EoT的概率.
评估不同流行病水平,治疗频率和遵守率对EoT的影响.

主要方法:

使用了基于个人的随机EPIONCHO-IBM模型.
模拟的年度和半年度MDA与ivermectin和moxidectin.
评估的情景是基线微菌的发病率为30%至70%,治疗覆盖率为65%或80%.

主要成果:

预计两年一度的莫西德MDA将在中端流行地区将EoT的时间减半.
两年一度的莫西德MDA可能是唯一能够在超大流行地区实现EoT的策略.
模型预测突显了对莫克西德克丁的长期影响和坚持模式的进一步数据的需求.

结论:

莫西德,特别是每两年一次的服用,提供了更有效的策略,可以消除的传播,而不是单独使用ivermectin.
优化MDA策略需要了解药物疗效,个体反应和坚持模式.
进一步的研究至关重要,以完善模型,并指导未来的公共卫生干预措施,以防止瘤病.

关键词:

在MDA中,MDA是MDA.我从来没有使用过mectin.大规模的药物管理.模拟建模的模型.莫克西德中毒素的使用方法在chocerciasis上进行确定.

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