饮食习惯与五种主要精神障碍之间的因果关系:一个双样本的门德尔随机化研究
Zhiqiang Du1, Shuaiyi Guo1, Yifan Sun1
1Wuxi Mental Health Center, Nanjing Medical University, Wuxi, Jiangsu, China.
Journal of affective disorders
|August 20, 2023
概括
避免小麦产品可能会降低患五种主要精神障碍的风险,包括抑郁症和精神分裂症. 相反,食用所有食物组与某些心理健康状况有积极的相关性.
科学领域:
- 营养精神病学 营养精神病学
- 遗传流行病学遗传流行病学
- 心理健康研究 心理健康研究
背景情况:
- 人们越来越认识到饮食习惯对心理健康的影响.
- 了解特定食物与精神疾病之间的因果关系对于公共卫生至关重要.
- 以前的研究表明存在关联,但因果关系的证据往往有限.
研究的目的:
- 研究特定饮食模式与五种主要精神障碍之间的潜在因果关系.
- 利用强大的遗传方法推断饮食和心理健康结果之间的因果关系.
- 分析来自欧洲人口的数据以进行概括性.
主要方法:
- 采用了两个样本的孟德尔随机化 (MR) 分析.
- 利用全基因组关联研究 (GWAS) 对饮食和精神障碍的总结数据.
- 专注于与"永远不要吃小麦产品"",永远不要吃糖"",我吃上述所有东西" (蛋,乳制品,小麦,糖) 相关的遗传位置.
主要成果:
- 在"永远不要吃小麦产品"和所有五种精神障碍 (躁狂,双相情感障碍,躁狂抑郁症,抑郁症,精神分裂症) 之间发现了显著的负相关性.
- 在"永远不要吃糖"和研究的精神障碍之间没有观察到显著的因果关系.
- "我吃上述所有食物"的饮食模式与躁狂症,双相情感障碍和躁狂抑郁症有显著的正相关性,但与抑郁症或精神分裂症无关.
结论:
- 避免小麦产品似乎与降低患五大精神障碍的风险有关.
- 在本分析中,饮食中的糖摄入量与研究的精神障碍没有显著的因果关系.
- 摄入包括蛋,乳制品,小麦和糖在内的饮食可能与某些心理健康状况 (如躁狂和双相情感障碍) 的风险增加有关.
更多相关视频
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.6K
09:10Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
10.8K
相关概念视频
Human Genetics
611
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
611
Cause and Effect
10.9K
While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
10.9K
Binge Eating Disorders
145
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
145
Theoretical Approaches to Psychological Disorder
254
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
254
Bulimia Nervosa
161
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
161
Psychological and Sociocultural Causes of Schizophrenia
138
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
138
