在NRG瘤学中对放射治疗质量保证的分析 RTOG 084848
Leila T Tchelebi1, Kathryn A Winter2, Ross A Abrams3
1Northwell, New Hyde Park, New York; Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
International journal of radiation oncology, biology, physics
|August 20, 2023
概括
在胰腺癌的放射治疗 (RT) 中,质量保证 (QA) 是至关重要的. 三分之一的患者需要修订治疗计划,这突出了临床试验中严格实时质量保证的必要性.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 临床试验 临床试验
背景情况:
- 胰腺头腺癌的治疗包括手术,随后是辅助化疗和潜在的放射治疗 (RT).
- 在NRG/辐射治疗瘤学小组0848试验中,研究了在辅助化疗后添加同步胺和RT的益处.
- 实时质量保证 (QA) 对于确保在RT临床试验中遵守协议至关重要.
研究的目的:
- 评估在切除胰腺头腺癌的随机试验中遵守协议规定的轮和治疗计划.
- 在RT规划期间报告需要修订的偏差的类型和频率.
主要方法:
- 使用基于网络的轮图谱和RT治疗量生成的逐步说明.
- 规划目标体积是临床治疗体积的均0.5厘米扩张.
- 放射瘤学专家对RT计划进行独立审查,需要对不可接受的偏差进行修订.
主要成果:
- 在包括在QA分析中的160名患者中,33%的患者至少需要重新提交一次治疗计划.
- 与强度调制RT (31%) 相比,对3维符合RT (43%) 的重新提交更为频繁.
- 重复提交的常见原因包括手术前总目标体积的偏差 (60.7%) 和胰腺结节术 (47.5%).
结论:
- 大约三分之一的患者需要重新提交治疗计划以满足协议的合规性.
- 实时,治疗前质量评估对于涉及胰腺癌RT的试验至关重要,以确保准确评估RT的真实效果.
- 技术质量评估过程为实践放射瘤学家提供了关于最佳实践的宝贵教育反.
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