通过从儿童时期的骨矿物质密度研究队列的双能量X射线吸收度来计算身体成分指数的参考范围
Babette S Zemel1, John A Shepherd2, Struan F A Grant3
1Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
The American journal of clinical nutrition
|August 20, 2023
概括
开发了新的双能X射线吸收度 (DXA) 参考范围,用于儿科身体组成. 这些范围基于多样化,低肥胖率队列,与NHANES数据相比显示出差异,有助于准确解释儿童生长和健康.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 身体组成分析 身体成分分析
- 公共卫生 营养 公共卫生 营养
背景情况:
- 准确的身体成分评估对于评估儿童生长,能量储存以及疾病和干预措施的影响至关重要.
- 目前的美国儿科参考范围 (NHANES) 包括很大比例的儿童患有肥胖 (≥95th BMI百分位数).
研究的目的:
- 建立基于双能X射线吸收度 (DXA) 的身体组成的儿科参考范围.
- 利用来自儿童骨矿物质密度研究 (BMDCS) 的肥胖率较低的多样化队列.
主要方法:
- 美国5个中心5岁至19岁健康儿童的纵向前性队列研究的二次分析.
- 每年进行全身DXA扫描,生成瘦软组织质量指数 (LSTM指数) 和脂肪质量指数 (FMI) 的参考范围.
- 开发了特定于性别和年龄的方程,以调整身体成分Z-scores与身高Z-scores.
主要成果:
- 2011年来自不同参与者的9846个扫描 (51%的女性,22%的黑人,17%的西班牙裔,48%的白人,7%的亚洲/太平洋岛民) 患有6%的肥胖症.
- 在中位数上,NHANES和BMDCS的参考曲线相似,但NHANES显示较高的+2 SD LSTM指数和FMI.
- 在附录的LSTM指数-Z和FMI-Z中观察到子组差异,在调整身高Z分数后变得更小.
结论:
- 已开发的参考范围补充了对儿科身体组成的有限规范性数据.
- BMDCS队列提供了一个有价值的资源,其肥胖率与当前的BMI图表相当.
- 识别子组差异对于准确解释儿科身体组成结果至关重要.
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