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关于Thlaspi arvense L L的尿酸减少的材料基础和机制的初步研究

Xiumei Ke¹, Xuan Yang², Chao Hou²

¹School of pharmacy, Chongqing Medical University, Chongqing, 400016, PR China.

Journal of ethnopharmacology

|August 20, 2023

概括

泰拉斯皮阿文斯通过抑制桑丁氧化酶和调节排泄,有效降低高尿血症 (HUA) 鼠的尿酸. 它的活性成分,有机酸和黄,减轻氧化应激和治疗HUA.

科学领域:

药理学药理学是指药理学的学科.
生物化学生物化学
传统中国医药传统中国医药

背景情况:

在西藏,Thlaspi arvense L. 传统上用于治疗高尿血症 (HUA).
初步研究表明,Thlaspi arvense可以降低HUA大鼠的尿酸.
对于HUA,Thlaspi arvense的活性成分和机制尚不清楚.

研究的目的:

在大鼠中研究Thlaspi arvense对HUA的活性成分.
阐明Thlaspi arvense在HUA治疗中的潜在机制.
使用网络药理学,UPLC-Q-TOF-MS,mRNA测序和RT-PCR.

主要方法:

使用氧酸盐和酵母提取物建立了一个超尿血病大鼠模型.
使用Thlaspi arvense (3.5g/kg),博马龙 (阳性对照) 或盐水.
使用网络药理学,UPLC-Q-TOF-MS,mRNA测序和RT-PCR进行分析.

主要成果:

泰拉斯皮阿文塞显著降低了血清尿酸,山丁氧化酶,肌素,尿素,AST,ALT和肝脏MDA.
网络药理学确定了40种活性化合物 (有机酸,黄类) 针对HUA途径.
通过mRNA测序和RT-PCR突出显示脏点SLC22A8,SLC12A1和SLC16A7参与尿酸代谢.

结论:

有机酸和黄可能是Thlaspi arvense对HUA的活性成分.
机制包括抑制丁氧化酶,调节脏尿酸运输,减少氧化应激.
拉斯皮阿文斯 (Thlaspi arvense) 显示出对高尿路血的治疗潜力.

关键词:

活动部件活动部件活动部件超性血症 (hyperuricemia) 是一种疾病,机理机制机理机制网络药理学网络药理学斯拉斯皮已经有了七年了.进行mRNA测序.

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